As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Five decades ago, seminal studies positioned the brainstem locus coeruleus (LC)
norepinephrine (NE) system as a key substrate for the regulation of wakefulness and sleep …

Background Sleep disturbances, including reduced nocturnal sleep time, sleep
fragmentation, nocturnal wandering, and daytime sleepiness are common clinical problems …

Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer's disease
(AD). While the fine-tuned coalescence of sleep microstructure elements may influence age …

Sleep plays a critical role in the process of memory consolidation. In particular, during non-
rapid eye movement (NREM) slow wave sleep, slow-oscillations, spindles, hippocampal …

Failed proteostasis is a well-documented feature of Alzheimer's disease, particularly,
reduced protein degradation and clearance. However, the contribution of failed proteostasis …

Background The brainstem locus coeruleus (LC) constitutes the intersection of the initial
pathophysiological processes of Alzheimer's disease (AD) and sleep-wake dysregulation in …

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …

Neurobiology and Neuroprotective Benefits of Sleep : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …

Sleep disturbances not only deteriorate alzheimer's disease (AD) progress by affecting
cognitive states but also accelerate the neuropathological changes of AD. Astrocytes and …