Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that
typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and …

Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

Poly (A) tails are non-templated additions of adenosines at the 3′ ends of most eukaryotic
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …

The proper processing, export, localization, translation, and degradation of mRNAs are
necessary for regulation of gene expression. These processes are controlled by mRNA …

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

Messenger RNA decay is an essential step in gene expression to set mRNA abundance in
the cytoplasm. The binding of proteins and/or noncoding RNAs to specific recognition …

Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs
containing a premature termination codon (PTC) and plays important roles in protein …

The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene
expression. Protein complexes recruited to 7mG mediate key processing events throughout …

In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that
is important for mRNA quality control. Following maturation of messenger ribonucleoprotein …