Oligonucleotide-based therapeutics have made rapid progress in the clinic for treatment of a
variety of disease indications. Unmodified oligonucleotides are polyanionic macromolecules …

DNA is a strikingly flexible molecule and can form a variety of secondary structures,
including the triple helix, which is the subject of this review. The DNA triplex may be formed …

Antisense-mediated modulation of splicing is one of the few fields where antisense
oligonucleotides (AONs) have been able to live up to their expectations. In this approach …

Among the multitude of chemical modifications that have been described over the past two
decades, oligonucleotide analogs that are modified at the 2′‐position of the furanose sugar …

We have recently shown that combining the structural elements of 2′ O-methoxyethyl
(MOE) and locked nucleic acid (LNA) nucleosides yielded a series of nucleoside …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents
US7314923B2 - Nucleoside and oligonucleotide analogues - Google Patents Nucleoside …

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …

Numerous chemically modified oligonucleotides have been developed so far and show their
own unique chemical properties and pharmacodynamic/pharmacokinetic characteristics …

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