Design, Synthesis, and Properties of 2',4'-BNANC: A Bridged Nucleic Acid Analogue
SM Abdur Rahman, S Seki, S Obika… - Journal of the …, 2008 - ACS Publications
The novel bridged nucleic-acid analogue 2 ', 4 '-BNANC (2 '-O, 4 '-C-aminomethylene
bridged nucleic acid), containing a six-membered bridged structure with an N− O linkage …
bridged nucleic acid), containing a six-membered bridged structure with an N− O linkage …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2013 - Google Patents
2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Positionally modified siRNA constructs
B Bhat, EE Swayze, TP Prakash, C Allerson… - US Patent …, 2013 - Google Patents
The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
Biological activity and biotechnological aspects of locked nucleic acids
KE Lundin, T Højland, BR Hansen, R Persson… - Advances in …, 2013 - Elsevier
Locked nucleic acid (LNA) is one of the most promising new nucleic acid analogues that has
been produced under the past two decades. In this chapter, we have tried to cover many of …
been produced under the past two decades. In this chapter, we have tried to cover many of …
[图书][B] Chemical synthesis of nucleoside analogues
P Merino - 2013 - Wiley Online Library
Nucleosides are the building blocks required in constructing nucleic acids. As we learned in
school, billions of combinations are possible using only four different nucleosides, and thus …
school, billions of combinations are possible using only four different nucleosides, and thus …
Chiral control
D Butler, N Iwamoto, N Svrzikapa, GL Verdine… - US Patent …, 2018 - Google Patents
The present invention relates to chirally controlled oligonucleotides, chirally controlled
oligonucleotide compositions, and the method of making and using the same. The invention …
oligonucleotide compositions, and the method of making and using the same. The invention …
[图书][B] PCR technology: current innovations
T Nolan, SA Bustin - 2013 - books.google.com
PCR's simplicity as a molecular technique is, in some ways, responsible for the huge
amount of innovation that surrounds it, as researchers continually think of new ways to …
amount of innovation that surrounds it, as researchers continually think of new ways to …
Influence of Sugar Modifications on the Nucleoside Conformation and Oligonucleotide Stability: A Critical Review
Ribofuranose sugar conformation plays an important role in the structure and dynamics of
functional nucleic acids such as siRNAs, AONs, aptamers, miRNAs, etc. To improve their …
functional nucleic acids such as siRNAs, AONs, aptamers, miRNAs, etc. To improve their …
[HTML][HTML] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice
T Takeuchi, K Maeta, X Ding, Y Oe, A Takeda… - … Therapy-Nucleic Acids, 2023 - cell.com
The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a
pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …