Impaired gating of γ‐and ε‐AChR respectively causes Escobar syndrome and fast‐channel myasthenia
XM Shen, T Nakata, S Mizuno, I Imoto… - Annals of Clinical …, 2023 - Wiley Online Library
Objective To dissect the kinetic defects of acetylcholine receptor (AChR) γ subunit variant in
an incomplete form of the Escobar syndrome without pterygium and compare it with those of …
an incomplete form of the Escobar syndrome without pterygium and compare it with those of …
A critical residue in the α1M2-M3 linker regulating GABAA receptor pore gating by diazepam
JW Nors, S Gupta, MP Goldschen-Ohm - bioRxiv, 2020 - biorxiv.org
Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs. Their
anxiolytic and sedative effects are conferred by modulating the activity of GABAA receptors …
anxiolytic and sedative effects are conferred by modulating the activity of GABAA receptors …
Estimating agonist efficiency from concentration-response curves
D Indurthi, A Auerbach - Authorea Preprints, 2020 - techrxiv.org
Background and Purpose: Agonists turn on receptors because they have higher affinity for
active versus resting conformations of their target sites. Agonist efficiency (distinct from …
active versus resting conformations of their target sites. Agonist efficiency (distinct from …
A Study of Structure and Function at Neurotransmitter Binding Sites of Nicotinic Receptors
S Tripathy - 2019 - search.proquest.com
Abstract In 1961, Jacques Monod said," I think I have discovered the second secret of life!".
This popular story was about" allosteric regulation", which is apparently the biochemical …
This popular story was about" allosteric regulation", which is apparently the biochemical …