Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
JR Rock, SH Randell… - Disease models & …, 2010 - journals.biologists.com
The small airways of the human lung undergo pathological changes in pulmonary disorders,
such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and …
such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and …
Toxicological Assessment of Inhaled Nanoparticles: Role of in Vivo, ex Vivo, in Vitro, and in Silico Studies
E Fröhlich, S Salar-Behzadi - International journal of molecular sciences, 2014 - mdpi.com
The alveolar epithelium of the lung is by far the most permeable epithelial barrier of the
human body. The risk for adverse effects by inhaled nanoparticles (NPs) depends on their …
human body. The risk for adverse effects by inhaled nanoparticles (NPs) depends on their …
Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …
Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication
YA Bochkov, K Watters, S Ashraf… - Proceedings of the …, 2015 - National Acad Sciences
Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and
asthma exacerbations compared with other rhinoviruses. The cellular receptor for these …
asthma exacerbations compared with other rhinoviruses. The cellular receptor for these …
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …
childhood, but the underlying mechanisms are poorly understood. We performed a genome …
Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data
Background The severity of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogeneous. Studies …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogeneous. Studies …
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs
Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …
key current challenges in molecular biology. Although gene expression and chromatin state …
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
Various acute and chronic inflammatory stimuli increase the number and activity of
pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus …
pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus …
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia
HM Mitchison, M Schmidts, NT Loges, J Freshour… - Nature …, 2012 - nature.com
Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …