Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC …

DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

Nonalcoholic steatohepatitis (NASH) is a progressive, inflammatory form of fatty liver
disease. It is the most rapidly rising risk factor for the development of hepatocellular …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …

In recent years, large scale genomics and genome-wide studies using comprehensive
genomic tools have reshaped our understanding of cancer evolution and heterogeneity …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, which develops
in the context of fibrosis and cirrhosis caused by chronic inflammation, in turn due to non …

Hepatocellular carcinoma (HCC) constitutes most primary liver cancers and is one of the
most lethal and life-threatening malignancies globally. Unfortunately, a substantial …

Living beings spend their lives and carry out their daily activities interacting with
environmental situations that present space-time variations and that involve contact with …

Novel insights into the epigenetic control of chronic liver diseases are now emerging.
Recent advances in our understanding of the critical roles of DNA methylation, histone …