Propofol is an intravenous short‐acting anesthetic widely used to induce and maintain
general anesthesia and to provide procedural sedation. The potential for propofol …

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature
for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus …

Human CYP2B6 enzyme although constitutes relatively low proportion (1–4%) of hepatic
cytochrome P450 content, it is the major catalyst of metabolism of several clinically important …

Objective. Personalized automatic control of medically-induced coma, a critical multi-day
therapy in the intensive care unit, could greatly benefit clinical care and further provide a …

Interindividual variability in response to drugs used in anesthesia has long been considered
the rule, not the exception. It is important to mention that in anesthesiology, the variability in …

The transition from wakefulness to general anesthesia is widely attributed to suppressive
actions of anesthetic molecules distributed by the systemic circulation to the cerebral cortex …

Implant surgery is a lengthy dental procedure, and sedation is often used to reduce
discomfort. The effectiveness of sedation has traditionally been evaluated in terms of patient …

A variety of techniques have been developed to monitor the depth of anaesthesia. Propofol's
pharmacokinetics and response vary greatly, which might be explained by genetic …

Abstract Background and Objectives Propofol is the most commonly used hypnotic
worldwide, but its effective dose varies greatly between individuals. The present study …

Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an
extensively metabolized intravenous anesthetic. In this study we examined the effect of the …