Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Rupture-
prone atheromas that give rise to myocardial infarction and stroke are characterized by the …

The clearance of apoptotic cells by macrophages (efferocytosis) prevents necrosis and
inflammation and activates pro-resolving pathways, including continual efferocytosis. A key …

BACKGROUND: The mTOR (mechanistic target of rapamycin) pathway is a complex
signaling cascade that regulates cellular growth, proliferation, metabolism, and survival …

Therapeutic approaches that lower circulating low-density lipoprotein (LDL)-cholesterol
significantly reduced the burden of cardiovascular disease over the last decades. However …

Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial
infarction (MI) repair. TREM2 has been proven to participate in phagocytosis and …

Efferocytosis is defined as the clearance of apoptotic cells (ACs) in physiological and
pathological states and is performed by efferocytes, such as macrophages. Efferocytosis can …

Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

Cardiovascular diseases remain the leading cause of death throughout the world.
Accumulation of lipoprotein-associated lipids and their interaction with macrophages are …

Targeting specific organs and cell types using nanotechnology and sophisticated delivery
methods has been at the forefront of applicative biomedical sciences lately. Macrophages …

Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance.
Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell …