CD8+ T cells play an important role in immunity to viruses. Just how important these cells
are is demonstrated by the evolution of viral strategies for blocking the generation or display …

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, cirrhosis, and
death; it is estimated that 180 million persons are infected with HCV worldwide. The …

The human and simian immunodeficiency viruses (HIV and SIV) downregulate the cell
surface expression of CD4. their primary receptor, and of class I histocompatibility complex …

Immunomodulators of pathogens frequently affect multiple cellular targets, thus preventing
recognition by different immune cells. For instance, the K5 modulator of immune recognition …

CD8+ T-cells are a critical component of the cellular immune response and they play an
important role in the control of viral infection. During HIV infection, CD8+ T-cells are able to …

Relatively small genomes and high replication rates allow viruses and bacteria to
accumulate mutations. This continuously presents the host immune system with new …

The macrophage mannose receptor, a pattern recognition molecule and component of
innate immunity, mediates binding and phagocytosis of Pneumocystis carinii and likely …

▪ Abstract Lentiviruses are associated with chronic diseases of the hematological and
neurological systems in animals and man. In particular, human immunodeficiency virus type …

1. ABSTRACT Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired
immune deficiency syndrome (AIDS), a disease characterized by CD4+ T lymphocyte …

Degradation of misfolded or tightly regulated proteins in the endoplasmic reticulum (ER) is
performed by the cytosolic ubiquitin-proteasome system and therefore requires their prior …