The intestine is fundamental in controlling human health. Intestinal epithelial and immune
cells are continuously exposed to millions of microbes that greatly impact on intestinal …

Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel
disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is …

Despite multiple associations between the microbiota and immune diseases, their role in
autoimmunity is poorly understood. We found that translocation of a gut pathobiont …

Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …

Of all microorganisms in the human body, the largest and most complex population resides
in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host …

Claudin family tight junction proteins form charge-and size-selective paracellular channels
that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is …

The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA)
metabolism, which is a complex physiological process involving multiple organs (liver …

The intestinal epithelium forms a highly dynamic and selective barrier that controls
absorption of fluid and solutes while restricting pathogen access to underlying tissues …