[HTML][HTML] Rosmarinic acid exhibits a lipid-lowering effect by modulating the expression of reverse cholesterol transporters and lipid metabolism in high-fat diet-fed mice
Hyperlipidemia is a potent risk factor for the development of cardiovascular diseases. The
reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and …
reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and …
Natural bio-active compounds
Secondary metabolites are the unique faction of compounds, produced by plants to protect
itself against the various biotic and abiotic factors (diseases, pests, pathogens, herbivores …
itself against the various biotic and abiotic factors (diseases, pests, pathogens, herbivores …
[HTML][HTML] Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats
AM Al-Attar, NA Shawush - Saudi journal of biological sciences, 2015 - Elsevier
The current study was undertaken to evaluate the protective activity of olive and rosemary
leaves extracts on experimental liver cirrhosis induced by thioacetamide (TAA) in Wistar …
leaves extracts on experimental liver cirrhosis induced by thioacetamide (TAA) in Wistar …
[HTML][HTML] Pharmacokinetics of rosmarinic acid in rats by LC-MS/MS: Absolute bioavailability and dose proportionality
J Wang, G Li, T Rui, A Kang, G Li, T Fu, J Li, L Di… - RSC advances, 2017 - pubs.rsc.org
Rosmarinic acid (RA), one of the main bioactive compounds of Rosmarinus officinalis L.,
exhibits diverse pharmacological effects. However, its oral absolute bioavailability and dose …
exhibits diverse pharmacological effects. However, its oral absolute bioavailability and dose …
[HTML][HTML] Lemon balm and its constituent, rosmarinic acid, alleviate liver damage in an animal model of nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease (NAFLD) ranges in severity from hepatic steatosis to
cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the …
cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the …
New trends in biotechnological production of rosmarinic acid
Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid, is widely
distributed in the plant kingdom. Interest in it is growing due to its promising biological …
distributed in the plant kingdom. Interest in it is growing due to its promising biological …
[HTML][HTML] Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs
YC Boo - Antioxidants, 2024 - mdpi.com
Fibrosis, which causes structural hardening and functional degeneration in various organs,
is characterized by the excessive production and accumulation of connective tissue …
is characterized by the excessive production and accumulation of connective tissue …
Protective effect of RA on myocardial infarction-induced cardiac fibrosis via AT1R/p38 MAPK pathway signaling and modulation of the ACE2/ACE ratio
Q Liu, J Tian, Y Xu, C Li, X Meng… - Journal of agricultural and …, 2016 - ACS Publications
Rosmarinic acid (α-o-caffeoyl-3, 4-dihydroxyphenyllactic acid, RA) is a major active
constituent of Rosmarinus officinalis Linn.(rosemary) having significant anti-inflammatory …
constituent of Rosmarinus officinalis Linn.(rosemary) having significant anti-inflammatory …
[HTML][HTML] The effect of antifibrotic drugs in rat precision-cut fibrotic liver slices
IM Westra, D Oosterhuis, GMM Groothuis, P Olinga - PLoS One, 2014 - journals.plos.org
Two important signaling pathways in liver fibrosis are the PDGF-and TGFβ pathway and
compounds inhibiting these pathways are currently developed as antifibrotic drugs. Testing …
compounds inhibiting these pathways are currently developed as antifibrotic drugs. Testing …
Protective effects and active ingredients of Salvia miltiorrhiza Bunge extracts on airway responsiveness, inflammation and remodeling in mice with ovalbumin-induced …
J Luo, L Zhang, X Zhang, Y Long, F Zou, C Yan, W Zou - Phytomedicine, 2019 - Elsevier
Background Salvia miltiorrhiza Bunge (S. miltiorrhiza), a traditional Chinese medicine, has
demonstrated antioxidant, anti-inflammatory, and antibacterial activities. However, its effects …
demonstrated antioxidant, anti-inflammatory, and antibacterial activities. However, its effects …