[HTML][HTML] Rosmarinic acid exhibits a lipid-lowering effect by modulating the expression of reverse cholesterol transporters and lipid metabolism in high-fat diet-fed mice

JB Nyandwi, YS Ko, H Jin, SP Yun, SW Park, HJ Kim - Biomolecules, 2021 - mdpi.com
Hyperlipidemia is a potent risk factor for the development of cardiovascular diseases. The
reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and …

Natural bio-active compounds

MS Akhtar, MK Swamy, UR Sinniah - Natural Bio-Active Compounds, 2019 - Springer
Secondary metabolites are the unique faction of compounds, produced by plants to protect
itself against the various biotic and abiotic factors (diseases, pests, pathogens, herbivores …

[HTML][HTML] Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats

AM Al-Attar, NA Shawush - Saudi journal of biological sciences, 2015 - Elsevier
The current study was undertaken to evaluate the protective activity of olive and rosemary
leaves extracts on experimental liver cirrhosis induced by thioacetamide (TAA) in Wistar …

[HTML][HTML] Pharmacokinetics of rosmarinic acid in rats by LC-MS/MS: Absolute bioavailability and dose proportionality

J Wang, G Li, T Rui, A Kang, G Li, T Fu, J Li, L Di… - RSC advances, 2017 - pubs.rsc.org
Rosmarinic acid (RA), one of the main bioactive compounds of Rosmarinus officinalis L.,
exhibits diverse pharmacological effects. However, its oral absolute bioavailability and dose …

[HTML][HTML] Lemon balm and its constituent, rosmarinic acid, alleviate liver damage in an animal model of nonalcoholic steatohepatitis

M Kim, GH Yoo, A Randy, YJ Son, CR Hong, SM Kim… - Nutrients, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) ranges in severity from hepatic steatosis to
cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the …

New trends in biotechnological production of rosmarinic acid

A Khojasteh, MH Mirjalili, D Hidalgo, P Corchete… - Biotechnology …, 2014 - Springer
Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid, is widely
distributed in the plant kingdom. Interest in it is growing due to its promising biological …

[HTML][HTML] Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs

YC Boo - Antioxidants, 2024 - mdpi.com
Fibrosis, which causes structural hardening and functional degeneration in various organs,
is characterized by the excessive production and accumulation of connective tissue …

Protective effect of RA on myocardial infarction-induced cardiac fibrosis via AT1R/p38 MAPK pathway signaling and modulation of the ACE2/ACE ratio

Q Liu, J Tian, Y Xu, C Li, X Meng… - Journal of agricultural and …, 2016 - ACS Publications
Rosmarinic acid (α-o-caffeoyl-3, 4-dihydroxyphenyllactic acid, RA) is a major active
constituent of Rosmarinus officinalis Linn.(rosemary) having significant anti-inflammatory …

[HTML][HTML] The effect of antifibrotic drugs in rat precision-cut fibrotic liver slices

IM Westra, D Oosterhuis, GMM Groothuis, P Olinga - PLoS One, 2014 - journals.plos.org
Two important signaling pathways in liver fibrosis are the PDGF-and TGFβ pathway and
compounds inhibiting these pathways are currently developed as antifibrotic drugs. Testing …

Protective effects and active ingredients of Salvia miltiorrhiza Bunge extracts on airway responsiveness, inflammation and remodeling in mice with ovalbumin-induced …

J Luo, L Zhang, X Zhang, Y Long, F Zou, C Yan, W Zou - Phytomedicine, 2019 - Elsevier
Background Salvia miltiorrhiza Bunge (S. miltiorrhiza), a traditional Chinese medicine, has
demonstrated antioxidant, anti-inflammatory, and antibacterial activities. However, its effects …