Aim The review summarizes the recent empirical evidence on the efficacy, safety, and
community perception of malaria vaccines in Africa. Methods Academic Search Complete …

Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium
falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) …

Background BK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based
on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to …

Background A blood-stage Plasmodium falciparum malaria vaccine would provide a second
line of defence to complement partially effective or waning immunity conferred by the …

By definition, all pathogens cause some level of harm to their hosts. If this harm occurs while
the pathogen is transmitting, it can negatively affect the pathogen's fitness by shortening the …

The call for second generation malaria vaccines needs not only the identification of novel
candidate antigens or adjuvants but also a better understanding of immune responses and …

Information on the dynamics and decline/persistence of antibody titres is important in
vaccine development. A recent vaccine trial in malaria-exposed, healthy African adults and …

Background A highly effective vaccine for malaria remains an elusive target, at least in part
due to the under-appreciated natural parasite variation. This study aimed to investigate …

Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5
(PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger …