With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Diabetes adversely affects wound-healing responses, leading to the development of chronic
infected wounds. Such wound microenvironment is characterized by hyperglycaemia …

Cardiac arterial bulbs of Skipjack tuna (Katsuwonus pelamis) are rich in elastin, and its
hydrolysates are high quality raw materials for daily cosmetics. In order to effectively utilizing …

The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to
persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly …

Morphine, a commonly used antinociceptive drug in hospitals, is known to cross the blood-
brain barrier (BBB) by first passing through brain endothelial cells. Despite its pain-relieving …

Background Exposure to particulate matter (PM) may contribute to lung inflammation and
injury. The therapeutic effect of N-acetylcysteine (NAC), a well-known antioxidant, with …

Musculoskeletal disorders include rheumatoid arthritis, osteoarthritis, sarcopenia, injury,
stiffness, and bone loss. The prevalence of these conditions is frequent among elderly …

Since environmental pollutants are ubiquitous and many of them are resistant to
degradation, we are exposed to many of them on a daily basis. Notably, these pollutants can …

Neutrophil extracellular traps (NETs) and oxidative stress are considered to be beneficial in
the innate immune defense against pathogens. However, defective clearance of NETs in the …