Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …

Asthma affects more than 300 million people worldwide and its prevalence is still rising.
Acute asthma attacks are characterized by severe symptoms such as breathlessness …

Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …

Metformin has been involved in modulating inflammatory state and inhibiting cell
proliferation and angiogenesis. This study aimed to determine whether metformin alleviates …

Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is
associated with disease severity in patients with chronic obstructive pulmonary disease …

In this work, we aim to analyze and compare the mechanisms controlling the volume of
mucus in the bronchial region of the lungs of a healthy human adult, at rest and in usual …

Background Bronchial thermoplasty (BT) is a novel technique used in the treatment of
subjects with severe refractory asthma. Radiofrequency is provided to airway walls during …

Common airborne allergens (pollen, animal dander and those from fungi and insects) are
the main triggers of type I allergic disorder in the respiratory system and are associated with …

Lung development is mediated by assorted signaling proteins and orchestrated by complex
mesenchymal-epithelial interactions. Notch signaling is an evolutionarily conserved cell-cell …