MicroRNA interplay between hepatic stellate cell quiescence and activation
D Ezhilarasan - European Journal of Pharmacology, 2020 - Elsevier
Hepatic stellate cells (HSCs) activation play a significant role in the progression of hepatic
fibrosis. During chronic liver diseases, hepatocytes are damaged severely and secrete …
fibrosis. During chronic liver diseases, hepatocytes are damaged severely and secrete …
[HTML][HTML] Pathophysiology and treatment options for hepatic fibrosis: can it be completely cured?
A Khanam, PG Saleeb, S Kottilil - Cells, 2021 - mdpi.com
Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …
[HTML][HTML] Hepatocyte-derived exosomal miR-27a activates hepatic stellate cells through the inhibition of PINK1-mediated mitophagy in MAFLD
X Luo, ZX Xu, JC Wu, SZ Luo, MY Xu - Molecular Therapy-Nucleic Acids, 2021 - cell.com
The role of exosome-mediated mitophagy in the crosstalk between hepatocytes (HCs) and
hepatic stellate cells (HSCs) in metabolic-associated fatty liver disease (MAFLD) remains …
hepatic stellate cells (HSCs) in metabolic-associated fatty liver disease (MAFLD) remains …
CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis
ZX Xu, JZ Li, Q Li, MY Xu, HY Li - Biochemical and Biophysical Research …, 2022 - Elsevier
Background Increasing evidences have confirmed the relationship between mitophagy and
nonalcoholic steatohepatitis (NASH). The exact mechanism of upstream circular RNAs …
nonalcoholic steatohepatitis (NASH). The exact mechanism of upstream circular RNAs …
[HTML][HTML] Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2
Objective Non-alcoholic fatty liver disease (NAFLD) involves hepatic accumulation of
intracellular lipid droplets via incompletely understood processes. Here, we report distinct …
intracellular lipid droplets via incompletely understood processes. Here, we report distinct …
[HTML][HTML] MicroRNA‑149‑3p inhibits cell proliferation by targeting AKT2 in oral squamous cell carcinoma
Q Shen, H Zhu, Q Lei, L Chen… - Molecular Medicine …, 2021 - spandidos-publications.com
MicroRNAs (miRs) exhibit oncogenic or tumor suppressive functions that contribute to the
initiation and development of various types of human cancer. miR‑149‑3p has been reported …
initiation and development of various types of human cancer. miR‑149‑3p has been reported …
[HTML][HTML] Interplays of liver fibrosis-associated microRNAs: molecular mechanisms and implications in diagnosis and therapy
Abstract microRNAs (miRNAs) are a class of non-coding functional small RNA composed of
21–23 nucleotides, having multiple associations with liver fibrosis. Fibrosis-associated …
21–23 nucleotides, having multiple associations with liver fibrosis. Fibrosis-associated …
[HTML][HTML] Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway
XX Gu, XX Xu, HH Liao, RN Wu, WM Huang… - Journal of …, 2021 - Springer
Background Liver injury seriously threatens the health of people. Meanwhile,
dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the …
dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the …
[HTML][HTML] RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat
L Sabater, L Locatelli, F Oakley, T Hardy, J French… - Scientific Reports, 2020 - nature.com
MicroRNAs are small (~ 22nt long) noncoding RNAs (ncRNAs) that regulate gene
expression at the post-transcriptional level. Over 2000 microRNAs have been described in …
expression at the post-transcriptional level. Over 2000 microRNAs have been described in …
Protective effect of Idelalisib on carbon tetrachloride‐induced liver fibrosis via microRNA‐124‐3P/phosphatidylinositol‐3‐hydroxykinase signalling pathway
X Li, H Li, S Zhang, R Zhang, J Li, Y Wei… - Journal of cellular …, 2021 - Wiley Online Library
Liver fibrosis is the repair process of abnormal connective tissue hyperplasia after liver
damage caused by different causes. Inhibition of PI3K/Akt signalling pathway can reduce the …
damage caused by different causes. Inhibition of PI3K/Akt signalling pathway can reduce the …