Bioactive compounds of edible fruits with their anti-aging properties: A comprehensive review to prolong human life

R Dhalaria, R Verma, D Kumar, S Puri, A Tapwal… - Antioxidants, 2020 - mdpi.com
Aging is a complicated biological process in which functional and structural alterations in a
living organism take place over time. Reactive oxygen species is one of the main factors …

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

G Tardiolo, P Bramanti, E Mazzon - Molecules, 2018 - mdpi.com
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

Modulation of neurotrophic signaling pathways by polyphenols

F Moosavi, R Hosseini, L Saso… - Drug design, development …, 2015 - Taylor & Francis
Polyphenols are an important class of phytochemicals, and several lines of evidence have
demonstrated their beneficial effects in the context of a number of pathologies including …

[HTML][HTML] Elevation of glutathione as a therapeutic strategy in Alzheimer disease

CB Pocernich, DA Butterfield - … et Biophysica Acta (BBA)-molecular basis of …, 2012 - Elsevier
Oxidative stress has been associated with the onset and progression of mild cognitive
impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display …

[HTML][HTML] Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

P Mecocci, MC Polidori - Biochimica et Biophysica Acta (BBA)-Molecular …, 2012 - Elsevier
Alzheimer's disease (AD) is a highly disabling progressive neurodegenerative disorder
characterized by a steadily growing number of patients, by the absence of a cure for the …

Medical and dietary uses of N-acetylcysteine

Š Šalamon, B Kramar, TP Marolt, B Poljšak, I Milisav - Antioxidants, 2019 - mdpi.com
N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to
glutathione. It has been used as a drug since the 1960s and is listed on the World Health …

Oxidative stress: A target to treat Alzheimer's disease and stroke

S Briyal, AK Ranjan, A Gulati - Neurochemistry International, 2023 - Elsevier
Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …