Effect of β-amyloid on blood-brain barrier properties and function

IY Petrushanko, VA Mitkevich, AA Makarov - Biophysical Reviews, 2023 - Springer
The deposition of beta-amyloid (Aβ) aggregates in the brain, accompanied by impaired
cognitive function, is a characteristic feature of Alzheimer's disease (AD). An important role …

Papel de los antioxidantes en la prevención del cáncer

L Llacuna, N Mach - Revista Española de Nutrición Humana y Dietética, 2012 - Elsevier
La naturaleza de la asociación entre radicales libres y cáncer es compleja y paradójica.
Parece que los radicales libres y el estrés oxidativo pueden inducir cáncer, pero al mismo …

[HTML][HTML] Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity

N Ismail, M Ismail, MU Imam, NH Azmi, SF Fathy… - … and alternative medicine, 2014 - Springer
Background Apoptosis is often the end result of oxidative damage to neurons. Due to shared
pathways between oxidative stress, apoptosis and antioxidant defence systems, an …

Synthetic and Natural Bioactive Molecules in Balancing the Crosstalk among Common Signaling Pathways in Alzheimer's Disease: Understanding the Neurotoxic …

AJ Shah, PA Mir, M Adnan, M Patel, M Maqbool… - ACS …, 2023 - ACS Publications
The structure and function of the brain greatly rely on different signaling pathways. The wide
variety of biological processes, including neurogenesis, axonal remodeling, the …

[HTML][HTML] Na, K-ATPase acts as a beta-amyloid receptor triggering src kinase activation

IY Petrushanko, AM Tverskoi, EP Barykin… - Cells, 2022 - mdpi.com
Beta-amyloid (Aβ) has a dual role, both as an important factor in the pathology of
Alzheimer's disease and as a regulator in brain physiology. The inhibitory effect of Aβ42 …

[HTML][HTML] Quercetin-3-O-β-D-glucuronide suppresses lipopolysaccharide-induced JNK and ERK phosphorylation in LPS-challenged RAW264. 7 cells

JY Park, MS Lim, SI Kim, HJ Lee, SS Kim… - Biomolecules & …, 2016 - ncbi.nlm.nih.gov
Quercetin, a flavonol, has been reported to exhibit a wide range of biological properties
including anti-oxidant and anti-inflammatory activities. However, pharmacological properties …

Small molecule natural products and Alzheimer's disease

X Wu, H Cai, L Pan, G Cui, F Qin… - Current topics in …, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive and deadly neurodegenerative disease that is
characterized by memory loss, cognitive impairment and dementia. Several hypotheses …

[HTML][HTML] Cyanidin 3-O-β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APPswe/PS1ΔE9 mouse …

N Song, L Zhang, W Chen, H Zhu, W Deng… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Alzheimer's disease (AD) is currently one of the most common neurodegenerative disorders
worldwide. To date, no cure has been developed for AD, and some disease-modifying …

Quercetin suppresses intracellular ROS formation, MMP activation, and cell motility in human fibrosarcoma cells

DE Lee, MY Chung, TG Lim, WB Huh… - Journal of food …, 2013 - Wiley Online Library
Cell metastasis is a major cause of death from cancer and can arise from excessive levels of
oxidative stress. The objective of this study was to investigate whether the natural flavonoid …

Neuroplasticity and successful cognitive aging: a brief overview for nursing

DE Vance, J Kaur, PL Fazeli, MH Talley… - Journal of …, 2012 - journals.lww.com
The brain remains dynamic even in older age and can benefit from mental exercises. Thus, it
is important to understand the concepts of positive and negative neuroplasticity and how …