The olfactory sense of the domestic dog is widely recognized as being highly sensitive with
a diverse function; however, little is known about the structure of its olfactory system. This …

Background: Evidence suggests patients prescribed calcineurin inhibitors (CNIs) have a
reduced prevalence of dementia, including Alzheimer's disease (AD); however, this result …

Simple Summary The median age of diagnosis of dementia, as well as for many cancers, is
above 60 years. Dementia should not exclude even frail, elderly patients from cancer …

Abstract Background Current treatments for Alzheimer's disease (AD) have largely failed to
yield significant therapeutic benefits. Novel approaches are desperately needed to help …

Despite the indispensable role that astrocytes play in the neurovascular unit, few studies
have investigated the functional impact of astrocyte signaling in cognitive decline and …

Aims With a focus on the discrepancy between preclinical and clinical findings, this review
will gather comprehensive information about the effects of calcineurin inhibitors (CNI) on …

Recent advances in diffusion-weighted imaging have enabled us to probe the microstructure
of even gray matter non-invasively. However, these advanced multi-shell protocols are often …

Introduction: Rise in Calcium (Ca2+) and hyperactive Ca2+-dependent phosphatase
calcineurin represent two key determinants of a-synuclein (a-syn) pathobiology implicated in …

Aging dogs serve as a valuable preclinical model for Alzheimer9s disease (AD) due to their
natural age-related development of β-amyloid (Aβ) plaques, human-like metabolism, and …

Drug repurposing can accelerate drug development while reducing the cost and risk of
toxicity typically associated with de novo drug design. Several disorders lacking …