Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review

L Ghosn, R Assi, T Evrenoglou… - Cochrane database …, 2023 - cochranelibrary.com
Background It has been reported that people with COVID‐19 and pre‐existing
autoantibodies against type I interferons are likely to develop an inflammatory cytokine storm …

[HTML][HTML] Effect of tocilizumab, sarilumab, and baricitinib on mortality among patients hospitalized for COVID-19 treated with corticosteroids: a systematic review and …

AM Albuquerque, I Eckert, L Tramujas… - Clinical Microbiology …, 2023 - Elsevier
Background Randomized controlled trials (RCT) established the mortality reduction by
tocilizumab (Actemra), baricitinib (Olumiant), and sarilumab (Kevzara) in hospitalized COVID …

Inflammasomes and IL-1 family cytokines in SARS-CoV-2 infection: from prognostic marker to therapeutic agent

J Declercq, E De Leeuw, BN Lambrecht - Cytokine, 2022 - Elsevier
Despite global vaccination programs, infections with severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity …

[HTML][HTML] Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments

SW Zhao, YM Li, YL Li, C Su - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) pandemic has been a serious threat to
global health for nearly 3 years. In addition to pulmonary complications, liver injury is not …

Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis

SY Yu, DH Koh, M Choi, S Ryoo, K Huh… - Emerging microbes & …, 2022 - Taylor & Francis
This study investigated the efficacy and safety of interleukin-6 (IL-6) receptor antagonists
with standard care treatment in patients with coronavirus disease 2019 (COVID-19). The …

Placebo effects on all‐cause mortality of patients with COVID‐19 in randomized controlled trials of interleukin 6 antagonists: A systematic review and network meta …

PT Tseng, BS Zeng, T Thompson… - Psychiatry and …, 2023 - Wiley Online Library
Aim Many randomized controlled trials (RCTs) have investigated the use of interleukin 6
antagonists for the treatment of coronavirus disease 2019 (COVID‐19), yielding inconsistent …

Care for adults with COVID‐19: living guidelines from the National COVID‐19 Clinical Evidence Taskforce

H White, SJ McDonald, B Barber… - Medical Journal of …, 2022 - Wiley Online Library
Abstract Introduction The Australian National COVID‐19 Clinical Evidence Taskforce was
established in March 2020 to maintain up‐to‐date recommendations for the treatment of …

[HTML][HTML] Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients

Y Leyfman, N Emmanuel, GP Menon, M Joshi… - Journal of Hematology & …, 2023 - Springer
Cancer patients, due to their immunocompromised status, are at an increased risk for severe
SARS-CoV-2 infection. Since severe SARS-CoV-2 infection causes multiple organ damage …

[HTML][HTML] Chlorpromazine, a clinically approved drug, inhibits SARS-CoV-2 nucleocapsid-mediated induction of IL-6 in human monocytes

I Karwaciak, K Karaś, A Sałkowska, J Pastwińska… - Molecules, 2022 - mdpi.com
The COVID-19 pandemic, caused by the rapidly spreading SARS-CoV-2 virus, led to the
unprecedented mobilization of scientists, resulting in the rapid development of vaccines and …

[HTML][HTML] Assessment of the available therapeutic approaches for severe COVID-19: a meta-analysis of randomized controlled trials

M Marko, R Pawliczak - Scientific Reports, 2023 - nature.com
The study aimed to evaluate severe COVID-19 treatment approaches. We conducted a meta-
analysis of randomized controlled trials (RTCs) with standard of care (SoC) as a control …