Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

S Bindu, S Mazumder, U Bandyopadhyay - Biochemical pharmacology, 2020 - Elsevier
Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory
drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in …

A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Rational multitargeted drug design strategy from the perspective of a medicinal chemist

X Li, X Li, F Liu, S Li, D Shi - Journal of Medicinal Chemistry, 2021 - ACS Publications
The development of multitarget-directed ligands (MTDLs) has become a widely focused
research topic, but rational design remains as an enormous challenge. This paper reviews …

[HTML][HTML] Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals

KR Patil, UB Mahajan, BS Unger, SN Goyal… - International journal of …, 2019 - mdpi.com
Inflammation is one of the common events in the majority of acute as well as chronic
debilitating diseases and represent a chief cause of morbidity in today's era of modern …

Hydrogen sulfide (H 2 S) releasing agents: chemistry and biological applications

Y Zhao, TD Biggs, M Xian - Chemical communications, 2014 - pubs.rsc.org
Hydrogen sulfide (H2S) is a newly recognized signaling molecule with very potent
cytoprotective actions. The fields of H2S physiology and pharmacology have been rapidly …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Toward hydrogen sulfide based therapeutics: critical drug delivery and developability issues

Y Zheng, B Yu, LK De La Cruz… - Medicinal Research …, 2018 - Wiley Online Library
Abstract Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO),
belongs to the gasotransmitter family and plays important roles in mammals as a signaling …

[HTML][HTML] H2S Donors and Their Use in Medicinal Chemistry

E Magli, E Perissutti, V Santagada, G Caliendo… - Biomolecules, 2021 - mdpi.com
Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important
role in many physiological and pathological processes in mammalian tissues, with the same …

[HTML][HTML] Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

A Corvino, F Frecentese, E Magli, E Perissutti… - Antioxidants, 2021 - mdpi.com
Hydrogen sulfide (H2S) is an endogenous gasotransmitter recently emerged as an
important regulatory mediator of numerous human cell functions in health and in disease. In …