The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …

Background Effective therapeutics to stop or reverse liver fibrosis have not emerged,
because these potential agents cannot specifically target activated hepatic stellate cells …

Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis,
as the last stage of numerous chronic liver diseases, is one of the most relevant prognostic …

Background Effective treatments for acute-on-chronic liver failure (ACLF) are lacking.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in …

Overdiagnosis refers to detection of disease that would not otherwise become clinically
apparent during a patient's lifetime. Overdiagnosis is common and has been reported for …

Background: The pandemic of coronavirus disease 2019 (COVID-19) has diverted
resources from healthcare services for patients with chronic medical illness such as cancer …

Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a medicinal herb that has been used for the
treatment for various diseases such as cardiovascular and cerebrovascular diseases in East …

Over the last two decades, our understanding of the pathological role of hepatic stellate cells
(HSCs) in fibrotic liver disease has increased dramatically. As HSCs are identified as the …

Patients with chronic liver disease (CLD) with or without cirrhosis remain at risk of
developing hepatic decompensation when infected with viral or bacterial pathogens. The …