Natural 3,4-dihydro-2(1h)-quinolinones- Part II: animal, bacterial, and fungal sources

S Khadem, RJ Marles - Natural Product Research, 2024 - Taylor & Francis
While natural products have undoubtedly played a pivotal role in drug discovery, their
potential as lead compounds has been hindered by challenges such as limited accessibility …

[HTML][HTML] Coumarin-1, 2, 3-triazole hybrids as leading-edge anticancer agents

KN Mishra, HC Upadhyay - Frontiers in Drug Discovery, 2022 - frontiersin.org
Cancer is one of the most feared and dreaded diseases across the world. In clinical practice,
a variety of anticancer agents of natural, semi-synthetic and synthetic origin exist, but they …

Visible-Light-Mediated Oxidative Cyclization of 2-Aminobenzyl Alcohols and Secondary Alcohols Enabled by an Organic Photocatalyst

J Xu, N Pan, J Chen, J Zhao - The Journal of Organic Chemistry, 2021 - ACS Publications
This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl
alcohols and secondary alcohols to produce quinolines at room temperature. This …

Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities …

Y Zhang, Q Wang, L Li, Y Le, L Liu, J Yang… - Journal of Enzyme …, 2021 - Taylor & Francis
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and
studied the preliminary structure-activity relationship for antiproliferative activities. All target …

[HTML][HTML] Chemical Composition of Combretum erythrophyllum Leaf and Stem Bark Extracts

S Bantho, Y Naidoo, YH Dewir, A Bantho, HN Murthy - Horticulturae, 2022 - mdpi.com
Combretaceae is a large Angiosperm family that is highly sought after because of its
pronounced medicinal value. Combretum is recognized as the largest genus, prevalent in …

Azole-based antibacterial agents: A review on multistep synthesis strategies and biology

J Devasia, A Nizam, V VL - Polycyclic Aromatic Compounds, 2022 - Taylor & Francis
This article reviews current multistep synthesis strategies of azole-based antibacterial
agents. In recent years, extensive use of chemical agents in treating different diseases …

Biology of quinoline and quinazoline alkaloids

XF Shang, SL Morris-Natschke, YQ Liu, XH Li… - The Alkaloids: Chemistry …, 2022 - Elsevier
Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic
compounds, have attracted scientific and popular interest worldwide since the 19th century …

Synthesis, biological evaluation and in silico computational studies of 7-chloro-4-(1 H-1, 2, 3-triazol-1-yl) quinoline derivatives: Search for new controlling agents …

DN Rosado-Solano, MA Barón-Rodríguez… - Journal of agricultural …, 2019 - ACS Publications
The insecticidal and antifeedant activities of five 7-chloro-4-(1 H-1, 2, 3-triazol-1-yl) quinoline
derivatives were evaluated against the maize armyworm, Spodoptera frugiperda (JE Smith) …

In Situ Sprayed Biotherapeutic Gel Containing Stable Microbial Communities for Efficient Anti‐Infection Treatment

JH Yan, DW Zheng, HY Gu, YJ Yu, JY Zeng… - Advanced …, 2023 - Wiley Online Library
Systematic administration of antibiotics to treat infections often leads to the rapid evolution
and spread of multidrug‐resistant bacteria. Here, an in situ‐formed biotherapeutic gel that …

Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization‐Cyclization Process

M Di Filippo, M Baumann - European Journal of Organic …, 2020 - Wiley Online Library
A continuous photochemical process is presented that renders a series of quinoline
products via an alkene isomerization and cyclocondensation cascade. It is demonstrated …