To develop new compounds with high activity, broad spectrum and low-toxicity, 17
benzamides substituted with quinoline-linked 1, 2, 4-oxadiazole were designed using the …

A practical method was developed for the convenient synthesis of isoxazole-fused tricyclic
quinazoline alkaloids. This procedure accesses diverse isoxazole-fused tricyclic quinazoline …

Quinoline derivatives are important natural products and pharmaceuticals, but their
synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of …

In this study, a series of 8-quinolinesulfonamide derivatives was synthesized, and their anti-
inflammatory activity was evaluated. Among them, compound 3l was found to be the best …

Combretaceae is a large medicinal family prevalent on the African continent. Traditional
healers commonly utilize species of this family to treat or cure a wide array of illnesses and …

Neocryptolepine derivatives have attracted great interest because of their unique cytotoxic
activity. 8-Fluoroneocryptolepine (8FNC) was synthesized, and its cytotoxicity was evaluated …

In this work, fifteen new substituted quinazoline analogs were synthesized in good yields
through the reaction of 7-(2-chloroethoxy)-6-methoxy-N-arylquinazoline-4-amine and …

Four novel cyclic enaminones, designated RD4123A− D (1− 4), and a new 4-quinazolinone
metabolite, RD4123E (5), were isolated from the culture extract of an unidentified …

We have developed the first I2/base-catalyzed regio-and stereoselective intermolecular β-
amidosulfonylation of terminal alkynes using sodium sulfinates and quinoxalinone …

Utilizing simple precursors for the exquisite construction of molecules with diversity and
complexity is urgent. Herein, a novel A3-X type reaction for functionalized 3-haloquinolines …