Adaptor/scaffold proteins serve as platforms for the assembly of multiprotein complexes and
regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an …

Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …

Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because
aberrant EGFR activity may cause cell transformation. Receptor-associated late transducer …

Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular
domains, each with distinct ligand preferences. Although ITSNs were initially implicated in …

The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus,
defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest …

Intersectin 1 (ITSN1) is an evolutionarily conserved adaptor protein involved in clathrin-
mediated endocytosis, cellular signaling and cytoskeleton rearrangement. ITSN1 gene is …

Background Ruk/CIN85 is a mammalian adaptor molecule with three SH3 domains. Using
its SH3 domains Ruk/CIN85 can cluster multiple proteins and protein complexes, and …

Invasive cancer cells form actin-rich membrane protrusions called invadopodia that degrade
extracellular matrix and facilitate cell invasion and metastasis. WIP (WASP-interacting …

T‐cell receptor (TCR) ligation‐mediated protein phosphorylation regulates the activation,
cellular responses, and fates of T cells. Here, we used time‐resolved high‐resolution …

WIP (WASP interacting protein) together with N-WASP (neural Wiskott-Aldrich syndrome
protein) regulates actin polymerization that is crucial for invadopodia and filopodia …