Smoking in schizophrenia: recent findings about an old problem

M Sagud, AM Peles, N Pivac - Current opinion in psychiatry, 2019 - journals.lww.com
Cigarette smoking continues to adversely affect the health of individuals with schizophrenia.
Both smoking and heavy nicotine dependence, given the complex biological findings, might …

Advanced materials to enhance central nervous system tissue modeling and cell therapy

RJ Muckom, RG Sampayo, HJ Johnson… - Advanced functional …, 2020 - Wiley Online Library
The progressively deeper understanding of mechanisms underlying stem cell fate decisions
has enabled parallel advances in basic biology—such as the generation of organoid models …

Investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the VTA using miRNA–mRNA analysis

T Kazemi, S Huang, NG Avci, CMK Waits, YM Akay… - Scientific reports, 2020 - nature.com
Nicotine and alcohol are two of the most commonly used and abused recreational drugs, are
often used simultaneously, and have been linked to significant health hazards. Furthermore …

Monitoring neural activities in the VTA in response to nicotine intake using a novel implantable microimaging device

Y Sunaga, Y Ohta, YM Akay, J Ohta, M Akay - IEEE Access, 2020 - ieeexplore.ieee.org
Measurements of the deep brain area of rodents has been one of the most important
methods to study deep brain activities, in part due to limited access of this region. In order to …

[HTML][HTML] Altered development of mesencephalic dopaminergic neurons in SIDS: New insights into understanding sudden infant death pathogenesis

AM Lavezzi - Biomedicines, 2021 - mdpi.com
Sudden infant death syndrome (SIDS) is defined as the unexpected sudden death of an
infant under 1 year of age that remains unexplained after a thorough case investigation. The …

Selecting relevant genes from microarray datasets using a random forest model

H Xia, YM Akay, M Akay - IEEE Access, 2021 - ieeexplore.ieee.org
Recent studies have demonstrated microarray expression data can be used to identify gene
regulatory pathways. However, one of the major challenges is to utilize the large microarray …

Repeated phencyclidine disrupts nicotinic acetylcholine regulation of dopamine release in nucleus accumbens: Implications for models of schizophrenia

E Yavas, AMJ Young - Neurochemistry International, 2020 - Elsevier
Dopaminergic dysregulation in nucleus accumbens has been implicated in the origin of
schizophrenia. Accumbal cholinergic interneurons exert powerful modulatory control of local …

Prenatal nicotine exposure alters gene expression profiles of neurons in the sub-regions of the VTA during early postnatal development

LD McGill, NG Avci, T Kazemi, Y Sunaga, YM Akay… - Scientific Reports, 2023 - nature.com
Brain growth occurs during the first 2 weeks of postnatal development in rats. This
developmental period is equivalent to the third trimester of human gestation. Dendritic …

Monitoring Neuronal Dynamics in the Ventral Tegmental Area Using an Implantable Microimaging Device with Microdialysis System

Y Sunaga, Y Ohta, TE Murakami, YM Akay… - IEEE …, 2021 - ieeexplore.ieee.org
To monitor dopamine neural activities in the ventral tegmental area (VTA) in response to
nicotine, we designed a dopamine platform based on a microimaging device and a …

Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA

T Kazemi, S Huang, NG Avci, YM Akay, M Akay - Scientific Reports, 2021 - nature.com
The ventral tegmental area (VTA) is the origin of dopaminergic neurons and the dopamine
(DA) reward pathway. This pathway has been widely studied in addiction and drug …