NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future
S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …
Synthetic and Medicinal Perspective of 1, 2, 4‐Triazole as Anticancer Agents
Cancer is still one of the leading causes of death worldwide. Many researchers are working
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …
[HTML][HTML] Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models
Naproxen is a common non-steroidal anti-inflammatory drug, which is the most usually used
propionic acid derivative for the treatment of many types of diseases. In this study, a series of …
propionic acid derivative for the treatment of many types of diseases. In this study, a series of …
Discovery of PIM-1 kinase inhibitors based on the 2, 5-disubstituted 1, 3, 4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo …
PIM-1 kinases play an established role in prostate cancer development and progression.
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …
Design, synthesis, and anticancer evaluation of novel tetracaine hydrazide-hydrazones
Mİ Han, N Imamoglu - ACS omega, 2023 - ACS Publications
Tetracaine is an ester derivative used as a local anesthetic molecule. In this study, a series
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …
Design, synthesis and anticancer activity studies of novel 4-butylaminophenyl hydrazide-hydrazones as apoptotic inducers
In this study, a series of the novel Tetracaine derivatives bearing hydrazide-hydrazone
moiety were designed, synthesized, and evaluated for anticancer activity. The structures of …
moiety were designed, synthesized, and evaluated for anticancer activity. The structures of …
Receptor mediated targeting of EGF-conjugated alginate-PAMAM nanoparticles to lung adenocarcinoma: 2D/3D in vitro and in vivo evaluation
E Ilhan-Ayisigi, P Saglam-Metiner, E Sanci… - International Journal of …, 2024 - Elsevier
Abstract Carboplatin (cis-diamine (1, 1-cyclobutandicarboxylaso)‑platinum (II)) is a second-
generation antineoplastic drug, which is widely used for chemotherapy of lung, colon …
generation antineoplastic drug, which is widely used for chemotherapy of lung, colon …
Thioethers: an overview
MI Han, Ŧ Küçükgüzel - Current drug targets, 2022 - ingentaconnect.com
Spreading rapidly in recent years, cancer has become one of the causes of the highest
mortality rates after cardiovascular diseases. The reason for cancer development is still not …
mortality rates after cardiovascular diseases. The reason for cancer development is still not …
In vitro evaluation and in vivo efficacy studies of a liposomal doxorubicin-loaded glycyrretinic acid formulation for the treatment of hepatocellular carcinoma
M Diril, KV Özdokur, Y Yıldırım… - Pharmaceutical …, 2023 - Taylor & Francis
Hepatocellular carcinoma (HCC), more than 800 000 cases reported annually, is the most
common primary liver cancer globally. Doxorubicin hydrochloride (Dox-HCl) is a widely …
common primary liver cancer globally. Doxorubicin hydrochloride (Dox-HCl) is a widely …