[HTML][HTML] Myostatin as a biomarker of muscle wasting and other pathologies-state of the art and knowledge gaps

J Baczek, M Silkiewicz, ZB Wojszel - Nutrients, 2020 - mdpi.com
Sarcopenia is a geriatric syndrome with a significant impact on older patients' quality of life,
morbidity and mortality. Despite the new available criteria, its early diagnosis remains …

[HTML][HTML] Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota

R Maslennikov, A Alieva, E Poluektova… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Decreased muscle mass and function, also known as sarcopenia, is common in patients
with cirrhosis and is associated with a poor prognosis. Although the pathogenesis of this …

[HTML][HTML] Brown adipose tissue controls skeletal muscle function via the secretion of myostatin

X Kong, T Yao, P Zhou, L Kazak, D Tenen… - Cell metabolism, 2018 - cell.com
Skeletal muscle and brown adipose tissue (BAT) are functionally linked, as exercise
increases browning via secretion of myokines. It is unknown whether BAT affects muscle …

Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis

Y Zhang, C Sun, Y Li, J Qin, K Amancherla… - Science translational …, 2022 - science.org
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer
treatment but are associated with myocarditis. Here, we report that tumor-bearing mice …

Cardiac cachexia: hic et nunc

G Loncar, J Springer, M Anker… - Journal of cachexia …, 2016 - Wiley Online Library
Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart
failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been …

Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy

A Greco, R Goossens, B Van Engelen… - Clinical …, 2020 - Wiley Online Library
Facioscapulohumeral muscular dystrophy (FSHD), a common hereditary myopathy, is
caused either by the contraction of the D4Z4 macrosatellite repeat at the distal end of …

Development of ovarian tumour causes significant loss of muscle and adipose tissue: a novel mouse model for cancer cachexia study

Y Luan, Y Zhang, SY Yu, M You, PC Xu… - Journal of cachexia …, 2022 - Wiley Online Library
Background Cancer‐associated cachexia (CAC) is a complex syndrome of progressive
muscle wasting and adipose loss with metabolic dysfunction, severely increasing the …

Sarcopenia: an endocrine disorder?

A McKee, JE Morley, AM Matsumoto, A Vinik - Endocrine Practice, 2017 - Elsevier
Sarcopenia is defined as low muscle function (walking speed or grip strength) in the
presence of low muscle mass. A simple screening test—the SARC-F—is available to identify …

The effects of resistance training on myostatin and follistatin in adults: a systematic review and meta-analysis

M Khalafi, B Aria, ME Symonds, SK Rosenkranz - Physiology & behavior, 2023 - Elsevier
Introduction and aim Myostatin and follistatin are the main hormones for regulating muscle
mass, and previous research suggests they are modulated by resistance training. We …

[HTML][HTML] Molecular mechanisms and current treatment options for cancer cachexia

SS Ahmad, K Ahmad, S Shaikh, HJ You, EY Lee, S Ali… - Cancers, 2022 - mdpi.com
Simple Summary The primary characteristics of cancer cachexia are weakness, weight loss,
atrophy, fat reduction, and systemic inflammation. Cachexia is strongly associated with …