Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

Angiogenesis plays crucial roles in various physiological processes including wound
healing and tissue repair. It requires a tight interaction between endothelial cells and their …

Background: The cells that form the arterial wall contribute to multiple vascular diseases.
The extent of cellular heterogeneity within these populations has not been fully …

Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …

Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels. This
highly regulated process take place through two non-exclusive events, the so-called …

Although the lung can undergo self-repair after injury, fibrosis in chronically injured or
diseased lungs can occur at the expense of regeneration. Here we study how a …

Tumor endothelial cells (ECs) promote cancer progression in ways beyond their role as
conduits supporting metabolism. However, it is unknown how vascular niche-derived …

The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-
angiogenic cancer therapy are major issues in almost all current concepts of both cancer …

Engineering of three-dimensional (3D) tissues is a promising approach for restoring
diseased or dysfunctional myocardium with a functional replacement. However, a major …