Long-term complications of COVID-19

AD Desai, M Lavelle… - American Journal of …, 2022 - journals.physiology.org
SARS-CoV-2 has rapidly spread across the globe and infected hundreds of millions of
people worldwide. As our experience with this virus continues to grow, our understanding of …

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Post-COVID-19 syndrome and the potential benefits of exercise

A Jimeno-Almazán, JG Pallarés… - International journal of …, 2021 - mdpi.com
The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2) infection, is leading to unknown and unusual health conditions …

Long-COVID and post-COVID health complications: an up-to-date review on clinical conditions and their possible molecular mechanisms

B Silva Andrade, S Siqueira, WR de Assis Soares… - Viruses, 2021 - mdpi.com
The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-
term care of COVID-19 survivors. It is thus imperative to study post-COVID (ie, short-term) …

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

MN Soares, M Eggelbusch, E Naddaf… - Journal of cachexia …, 2022 - Wiley Online Library
Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

Association of obesity with COVID-19 severity and mortality: an updated systemic review, meta-analysis, and meta-regression

R Singh, SS Rathore, H Khan, S Karale… - Frontiers in …, 2022 - frontiersin.org
Background Obesity affects the course of critical illnesses. We aimed to estimate the
association of obesity with the severity and mortality in coronavirus disease 2019 (COVID …

Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

S Jarius, F Pache, P Körtvelyessy, I Jelčić… - Journal of …, 2022 - Springer
Background Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with
COVID-19 and neurological involvement from large-scale multicenter studies are missing so …

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

R Hashimoto, J Takahashi, K Shirakura, R Funatsu… - Science …, 2022 - science.org
In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers …

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

JP Robles, M Zamora, E Adan-Castro… - Journal of Biological …, 2022 - ASBMB
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that
maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in …

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

F Liu, K Han, R Blair, K Kenst, Z Qin, B Upcin… - Frontiers in cellular …, 2021 - frontiersin.org
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …