Pharmacology of adenosine receptors: Recent advancements
F Vincenzi, S Pasquini, C Contri, M Cappello, M Nigro… - Biomolecules, 2023 - mdpi.com
Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …
Role of microglia in stroke
AM Planas - Glia, 2024 - Wiley Online Library
Microglia play key roles in the post‐ischemic inflammatory response and damaged tissue
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer's disease, ischemic brain injury, and epileptic state
YH Ahn, Y Tang, P Illes - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
Introduction Astrocytes have previously been considered as cells supporting neuronal
functions, but they are now recognized as active players in maintaining central nervous …
functions, but they are now recognized as active players in maintaining central nervous …
Generation and characterization of antagonistic anti-human CD39 nanobodies
S Menzel, Y Duan, J Hambach, B Albrecht… - Frontiers in …, 2024 - frontiersin.org
CD39 is the major enzyme controlling the levels of extracellular adenosine triphosphate
(ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine …
(ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine …
Extracellular ATP/adenosine dynamics in the brain and its role in health and disease
E Shigetomi, K Sakai, S Koizumi - Frontiers in Cell and …, 2024 - frontiersin.org
Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal
functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic …
functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic …
Inhibition of usp30 promotes mitophagy by regulating ubiquitination of mfn2 by parkin to attenuate early brain injury after sah
Y Liu, C Yao, B Sheng, S Zhi, X Chen, P Ding… - Translational Stroke …, 2023 - Springer
Subarachnoid hemorrhage (SAH) is a type of stroke with a high disability and mortality rate.
Apoptosis caused by massive damage to mitochondria in neuron cells and inflammatory …
Apoptosis caused by massive damage to mitochondria in neuron cells and inflammatory …
A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis
M Wendlandt, AJ Kürten, A Beiersdorfer… - Frontiers in …, 2023 - frontiersin.org
Introduction The cyclic nucleotide cyclic adenosine monophosphate (cAMP) is a ubiquitous
second messenger, which is known to play an important anti-inflammatory role. Astrocytes in …
second messenger, which is known to play an important anti-inflammatory role. Astrocytes in …
GV‐971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities
X Yang, Z Zhangyi, A Yu, Q Zhou, A Xia… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Growing evidence suggests that an imbalanced gut microbiota composition plays a
crucial role in the development of neuromyelitis optica spectrum disorders (NMOSD), an …
crucial role in the development of neuromyelitis optica spectrum disorders (NMOSD), an …
[HTML][HTML] Salidroside improves cognitive function in Parkinson's disease via Braf-mediated mitogen‑activated protein kinase signaling pathway
S Lu, N Ji, W Wang, X Lin, D Gao, D Geng - Biomedicine & …, 2024 - Elsevier
Objective To delve into the underlying mechanism of Salidroside (Sal) on the improvement
of cognitive function in Parkinson's Disease (PD). Methods The experimental mice were …
of cognitive function in Parkinson's Disease (PD). Methods The experimental mice were …
[HTML][HTML] Discovering Novel Plasma Biomarkers for Ischemic Stroke: Lipidomic and Metabolomic Analyses in an Aged Mouse Model
DA Becktel, JB Frye, EH Le, SA Whitman… - Journal of Lipid …, 2024 - Elsevier
Ischemic stroke remains a leading cause of mortality and long-term disability worldwide,
necessitating efforts to identify biomarkers for diagnosis, prognosis, and treatment …
necessitating efforts to identify biomarkers for diagnosis, prognosis, and treatment …