Recent development in zebrafish model for bioactivity and safety evaluation of natural products

FJ Lin, H Li, DT Wu, QG Zhuang, HB Li… - Critical Reviews in …, 2022 - Taylor & Francis
The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several
advantageous features have facilitated zebrafish to be extensively utilized as a valuable …

Fish models of induced osteoporosis

JT Rosa, V Laizé, PJ Gavaia… - Frontiers in Cell and …, 2021 - frontiersin.org
Osteopenia and osteoporosis are bone disorders characterized by reduced bone mineral
density (BMD), altered bone microarchitecture and increased bone fragility. Because of …

Identification of kaempferol as an OSX upregulator by network pharmacology-based analysis of qianggu Capsule for osteoporosis

AY Huang, Z Xiong, K Liu, Y Chang, L Shu… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is the most common metabolic disease of skeleton with reduced bone density
and weaker bone. Qianggu Capsule as a traditional chinese medicine has been widely …

Er-Xian decoction attenuates ovariectomy-induced osteoporosis by modulating fatty acid metabolism and IGF1/PI3K/AKT signaling pathway

Y Ma, J Hu, C Song, P Li, Y Cheng, Y Wang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Er-Xian decoction (EXD) is a traditional Chinese
medicine (TCM) formula used to treat osteoporosis (OP). However, the anti-OP mechanism …

Magnoflorine ameliorates collagen-induced arthritis by suppressing the inflammation response via the NF-κB/MAPK signaling pathways

L Wang, P Li, Y Zhou, R Gu, G Lu… - Journal of Inflammation …, 2023 - Taylor & Francis
Objective Magnoflorine (Mag) has been reported to have anxiolytics, anti-cancer, and anti-
inflammatory properties. In this study, we aim to investigate the effects of Mag on the …

Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells

P Wu, F Jiao, H Huang, D Liu, W Tang… - Pharmaceutical …, 2022 - Taylor & Francis
Abstract Context Morinda officinalis FC How.(MO)(Rubiaceae) can strengthen bone function.
Objective To examine the functional mechanism and effect of MO polysaccharides (MOPs) in …

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

HH Nam, JS Kim, J Lee, YH Seo, HS Kim, SM Ryu… - Biomolecules, 2020 - mdpi.com
Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases.
However, the active ingredients and pharmacological targets of A. rugosa are unknown. In …

Exploring the pharmacological mechanism of duhuo jisheng decoction in treating osteoporosis based on network pharmacology

Z Xiong, C Zheng, Y Chang, K Liu… - Evidence‐Based …, 2021 - Wiley Online Library
Objective. The purpose of this work is to study the mechanism of action of Duhuo Jisheng
Decoction (DHJSD) in the treatment of osteoporosis based on the methods of bioinformatics …

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis

W Xie, H Yang, C Guo, R Xie, G Yu… - … Design, Development and …, 2023 - Taylor & Francis
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints
associated with systemic comorbidities. Sinomenium acutum is regarded as an effective …

Study on the Mechanism of the Danggui–Chuanxiong Herb Pair on Treating Thrombus through Network Pharmacology and Zebrafish Models

M Zhang, P Li, S Zhang, X Zhang, L Wang, Y Zhang… - ACS …, 2021 - ACS Publications
Danggui–Chuanxiong (DC) is a commonly used nourishing and activating blood medicine
pair in many gynecological prescriptions and modern Chinese medicine. However, its …