Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis

D Zheng, J Liu, H Piao, Z Zhu, R Wei, K Liu - Frontiers in immunology, 2022 - frontiersin.org
The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …

[HTML][HTML] Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular …

Q Zhang, J Liu, H Duan, R Li, W Peng, C Wu - Journal of advanced …, 2021 - Elsevier
Abstract Introduction Recently, Nrf2/HO-1 has received extensive attention as the main
regulatory pathway of intracellular defense against oxidative stress and is considered an …

Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors

JL Silveira Rossi, SM Barbalho… - Diabetes/metabolism …, 2022 - Wiley Online Library
Metabolic syndrome (MS) is a chronic non‐infective syndrome characterised clinically by a
set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity …

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

T Zhao, W Wu, L Sui, Q Huang, Y Nan, J Liu, K Ai - Bioactive Materials, 2022 - Elsevier
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …

Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes

T Münzel, O Hahad, M Kuntic, JF Keaney Jr… - European heart …, 2020 - academic.oup.com
Tobacco smoking is a leading cause of non-communicable disease globally and is a major
risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by …

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

J Fang, W Islam, H Maeda - Advanced drug delivery reviews, 2020 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

Emerging roles of energy metabolism in ferroptosis regulation of tumor cells

X Yao, W Li, D Fang, C Xiao, X Wu, M Li… - Advanced …, 2021 - Wiley Online Library
Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐
dependent accumulation of lethal lipid peroxides and involved in many critical diseases …