[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation
NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …
expression. The identification of the actual splice sites and the proper removal of introns are …
[HTML][HTML] Role of main RNA methylation in hepatocellular carcinoma: N6-methyladenosine, 5-methylcytosine, and N1-methyladenosine
Y Xu, M Zhang, Q Zhang, X Yu, Z Sun, Y He… - Frontiers in cell and …, 2021 - frontiersin.org
RNA methylation is considered a significant epigenetic modification, a process that does not
alter gene sequence but may play a necessary role in multiple biological processes, such as …
alter gene sequence but may play a necessary role in multiple biological processes, such as …
Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing
Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …
2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states
O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …
important biological roles through mechanisms that are not entirely understood. There is …
Exploring the epitranscriptome by native RNA sequencing
Chemical RNA modifications, collectively referred to as the “epitranscriptome,” are essential
players in fine-tuning gene expression. Our ability to analyze RNA modifications has …
players in fine-tuning gene expression. Our ability to analyze RNA modifications has …
Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm
Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-
transcriptional regulation during spermatogenesis with particular emphasis on the role of …
transcriptional regulation during spermatogenesis with particular emphasis on the role of …
[PDF][PDF] The Alazami syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness
The La-related protein 7 (LARP7) forms a complex with the nuclear 7SK RNA to regulate
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …
DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6. U5 tri-snRNP assembly and pre-mRNA splicing fidelity
The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified
post-transcriptionally, with 2'-O-methylation being most common. However, how U6 2'-O …
post-transcriptionally, with 2'-O-methylation being most common. However, how U6 2'-O …
The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme
The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
Aging through an epitranscriptomic lens
The mechanistic causes of aging, the time-related decline in function and good health that
leads to increased mortality, remain poorly understood. Here we propose that age …
leads to increased mortality, remain poorly understood. Here we propose that age …