Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the
stability and regulation of the endocrine system of the body or its offspring. These …

Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

STUDY QUESTION What is the physiological extent of vascular remodelling in and
trophoblast plugging of the uterine circulation across the first half of pregnancy? SUMMARY …

Uteroplacental blood flow increases as pregnancy advances. Adequate supply of nutrients
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …

Adverse effects associated with chemical exposures during pregnancy include several
developmental and reproductive disorders. However, considering the tens of thousands of …

A major challenge to treating diseases during pregnancy is that small molecule therapeutics
are transported through the placenta and incur toxicities to the developing fetus. The …

Chronic hypoxia is a common cause of pulmonary hypertension, preeclampsia, and
intrauterine growth restriction (IUGR). The molecular mechanisms underlying these …

Human pregnancy relies on hemochorial placentation, including implantation of the
blastocyst and deep invasion of fetal trophoblast cells into maternal uterine blood vessels …