Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …

Haematopoietic stem cells (HSCs) circulate in the bloodstream under steady-state
conditions, but the mechanisms controlling their physiological trafficking are unknown. Here …

Success with transplantation of autologous hematopoietic stem and progenitor cells
(HSPCs) in patients depends on adequate collection of these cells after mobilization from …

Accumulating evidence indicates that interaction of stromal cell-derived factor 1 (SDF-
1/CXCL12 [CXC motif, ligand 12]) with its cognate receptor, CXCR4 (CXC motif, receptor 4) …

There are growing data to suggest that tissue hypoxia represents a critical force that drives
adult vasculogenesis. Vascular endothelial growth factor (VEGF) expression is dramatically …

Blood plays an important role in homeostatic regulation with each of its cellular components
having important therapeutic and diagnostic uses. Therefore, separation and sorting of …

Abstract AMD3100 given with G-CSF has been shown to mobilize CD34+ cells in non-
Hodgkin's lymphoma (NHL), multiple myeloma (MM), and Hodgkin's disease (HD) patients …

Current evidence suggests that hematopoietic stem/progenitor cell (HSPC) mobilization by
granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow …

Review discusses evidence that the bone marrow is an important site of neutrophil
clearance under homeostatic conditions. Abstract Neutrophils, an essential component of …