Type 1 diabetes: etiology, immunology, and therapeutic strategies
TL Van Belle, KT Coppieters… - Physiological …, 2011 - journals.physiology.org
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …
The hematopoietic stem cell niche in homeostasis and disease
LM Calvi, DC Link - Blood, The Journal of the American Society …, 2015 - ashpublications.org
The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …
Haematopoietic stem cell release is regulated by circadian oscillations
Haematopoietic stem cells (HSCs) circulate in the bloodstream under steady-state
conditions, but the mechanisms controlling their physiological trafficking are unknown. Here …
conditions, but the mechanisms controlling their physiological trafficking are unknown. Here …
Diabetes impairs hematopoietic stem cell mobilization by altering niche function
F Ferraro, S Lymperi, S Méndez-Ferrer… - Science translational …, 2011 - science.org
Success with transplantation of autologous hematopoietic stem and progenitor cells
(HSPCs) in patients depends on adequate collection of these cells after mobilization from …
(HSPCs) in patients depends on adequate collection of these cells after mobilization from …
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
CL Semerad, MJ Christopher, F Liu, B Short… - Blood, 2005 - ashpublications.org
Accumulating evidence indicates that interaction of stromal cell-derived factor 1 (SDF-
1/CXCL12 [CXC motif, ligand 12]) with its cognate receptor, CXCR4 (CXC motif, receptor 4) …
1/CXCL12 [CXC motif, ligand 12]) with its cognate receptor, CXCR4 (CXC motif, receptor 4) …
VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at site of tumor neovascularization
B Li, EE Sharpe, AB Maupin, AA Teleron… - The FASEB …, 2006 - Wiley Online Library
There are growing data to suggest that tissue hypoxia represents a critical force that drives
adult vasculogenesis. Vascular endothelial growth factor (VEGF) expression is dramatically …
adult vasculogenesis. Vascular endothelial growth factor (VEGF) expression is dramatically …
Microfluidic blood cell sorting: now and beyond
Blood plays an important role in homeostatic regulation with each of its cellular components
having important therapeutic and diagnostic uses. Therefore, separation and sorting of …
having important therapeutic and diagnostic uses. Therefore, separation and sorting of …
AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing …
G Calandra, J McCarty, J McGuirk, G Tricot… - Bone marrow …, 2008 - nature.com
Abstract AMD3100 given with G-CSF has been shown to mobilize CD34+ cells in non-
Hodgkin's lymphoma (NHL), multiple myeloma (MM), and Hodgkin's disease (HD) patients …
Hodgkin's lymphoma (NHL), multiple myeloma (MM), and Hodgkin's disease (HD) patients …
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
MJ Christopher, F Liu, MJ Hilton… - Blood, The Journal of …, 2009 - ashpublications.org
Current evidence suggests that hematopoietic stem/progenitor cell (HSPC) mobilization by
granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow …
granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow …
The bone marrow: a site of neutrophil clearance
SM Rankin - Journal of leukocyte biology, 2010 - academic.oup.com
Review discusses evidence that the bone marrow is an important site of neutrophil
clearance under homeostatic conditions. Abstract Neutrophils, an essential component of …
clearance under homeostatic conditions. Abstract Neutrophils, an essential component of …