The evolutionarily conserved Notch signalling pathway regulates the differentiation and
function of mature T lymphocytes with major context-dependent consequences in host …

Notch signaling is an evolutionarily conserved cell-to-cell signaling pathway that regulates
cellular differentiation and function across multiple tissue types and developmental stages …

Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …

We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …

The fungal genus Cryptococcus comprises a group of pathogens with considerable
phenotypic and genotypic diversity that can lead to cryptococcosis in both healthy and …

Exposure to ionizing radiation often induces T helper (Th) cell differentiation, resulting in an
imbalance of Th1 and Th2 cellular subtypes, which can affect the efficacy of cancer …

Notch signaling is emerging as a critical regulator of T cell activation and function. However,
there is no reliable cell surface indicator of Notch signaling across activated T cell subsets …

Notch signaling, an evolutionarily conserved signal pathway has emerged as a key signal
pathway to regulate host immune response but the contribution of Notch signaling to …

We have recently reported that transcription factor Runx3 is required for pulmonary
generation of CD8+ cytotoxic T lymphocytes (CTLs) that play a crucial role in the clearance …

Helicobacter pylori infection induces CD4+ T differentiation cells into IFN-γ-producing Th1
cells. However, the details of mechanism underlying this process remain unclear. Notch …