The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
The neuroscience of drug reward and addiction
ND Volkow, M Michaelides, R Baler - Physiological reviews, 2019 - journals.physiology.org
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …
International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Volitional social interaction prevents drug addiction in rat models
Addiction treatment has not been appreciably improved by neuroscientific research. One
problem is that mechanistic studies using rodent models do not incorporate volitional social …
problem is that mechanistic studies using rodent models do not incorporate volitional social …
Animal models of drug relapse and craving after voluntary abstinence: a review
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …
several decades, this clinical scenario has been studied at the preclinical level using classic …
Sex differences in opioid and psychostimulant craving and relapse: a critical review
A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …
than males to drug craving and relapse. Here, we first review clinical studies on sex …
[HTML][HTML] Reward circuitry in addiction
S Cooper, AJ Robison, MS Mazei-Robison - Neurotherapeutics, 2017 - Elsevier
Understanding the brain circuitry that underlies reward is critical to improve treatment for
many common health issues, including obesity, depression, and addiction. Here we focus …
many common health issues, including obesity, depression, and addiction. Here we focus …
Epigenetic mechanisms of opioid addiction
Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …
communities, and cripples the health care system. Exposure to opioids causes long-term …
[HTML][HTML] Dorsal striatal circuits for habits, compulsions and addictions
DM Lipton, BJ Gonzales, A Citri - Frontiers in systems neuroscience, 2019 - frontiersin.org
Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors
which are all characterized by relatively automatic action performance. We discuss relevant …
which are all characterized by relatively automatic action performance. We discuss relevant …
Homeostasis meets motivation in the battle to control food intake
Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …