The transition to compulsion in addiction

C Lüscher, TW Robbins, BJ Everitt - Nature Reviews Neuroscience, 2020 - nature.com
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …

The neuroscience of drug reward and addiction

ND Volkow, M Michaelides, R Baler - Physiological reviews, 2019 - journals.physiology.org
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

NM Barnes, GP Ahern, C Becamel, J Bockaert… - Pharmacological …, 2021 - ASPET
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Volitional social interaction prevents drug addiction in rat models

M Venniro, M Zhang, D Caprioli, JK Hoots… - Nature …, 2018 - nature.com
Addiction treatment has not been appreciably improved by neuroscientific research. One
problem is that mechanistic studies using rodent models do not incorporate volitional social …

Animal models of drug relapse and craving after voluntary abstinence: a review

I Fredriksson, M Venniro, DJ Reiner, JJ Chow… - Pharmacological …, 2021 - ASPET
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Sex differences in opioid and psychostimulant craving and relapse: a critical review

C Nicolas, NE Zlebnik, M Farokhnia, L Leggio… - Pharmacological …, 2022 - ASPET
A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …

[HTML][HTML] Reward circuitry in addiction

S Cooper, AJ Robison, MS Mazei-Robison - Neurotherapeutics, 2017 - Elsevier
Understanding the brain circuitry that underlies reward is critical to improve treatment for
many common health issues, including obesity, depression, and addiction. Here we focus …

Epigenetic mechanisms of opioid addiction

CJ Browne, A Godino, M Salery, EJ Nestler - Biological psychiatry, 2020 - Elsevier
Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

[HTML][HTML] Dorsal striatal circuits for habits, compulsions and addictions

DM Lipton, BJ Gonzales, A Citri - Frontiers in systems neuroscience, 2019 - frontiersin.org
Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors
which are all characterized by relatively automatic action performance. We discuss relevant …

Homeostasis meets motivation in the battle to control food intake

CR Ferrario, G Labouèbe, S Liu, EH Nieh… - Journal of …, 2016 - Soc Neuroscience
Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …