The etiology of preeclampsia

E Jung, R Romero, L Yeo, N Gomez-Lopez… - American journal of …, 2022 - Elsevier
Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlapping pathologic processes activate a common pathway consisting of endothelial cell …

Clinical, pathophysiologic, genetic, and therapeutic progress in primary bilateral macronodular adrenal hyperplasia

J Bertherat, I Bourdeau, L Bouys… - Endocrine …, 2023 - academic.oup.com
Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present
bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol …

The immune system in Cushing's syndrome

V Hasenmajer, E Sbardella, F Sciarra… - Trends in endocrinology …, 2020 - cell.com
Cushing's syndrome (CS), or chronic hypercortisolism, induces a variety of alterations in the
immune system, often leading to severe clinical complications such as sepsis and …

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Y Baumer, MA Pita, AS Baez… - Clinical …, 2023 - portlandpress.com
While it is well known from numerous epidemiologic investigations that social determinants
(socioeconomic, environmental, and psychosocial factors exposed to over the life-course) …

Long‐term health consequences of congenital adrenal hyperplasia

R Pofi, X Ji, NP Krone, JW Tomlinson - Clinical Endocrinology, 2023 - Wiley Online Library
Congenital adrenal hyperplasia (CAH) caused by 21‐hydroxylase deficiency accounts for
95% of all CAH cases and is one of the most common inborn metabolic conditions. The …

Cortisol excess in patients with primary aldosteronism impacts left ventricular hypertrophy

C Adolf, A Köhler, A Franke, K Lang… - The Journal of …, 2018 - academic.oup.com
Context Primary aldosteronism (PA) represents the most frequent form of endocrine
hypertension. Hyperaldosteronism and hypercortisolism both induce excessive left …

Sodium handling and interaction in numerous organs

S Minegishi, FC Luft, J Titze… - American journal of …, 2020 - academic.oup.com
Salt (NaCl) is a prerequisite for life. Excessive intake of salt, however, is said to increase
disease risk, including hypertension, arteriosclerosis, heart failure, renal disease, stroke …

[HTML][HTML] Levoketoconazole in the treatment of patients with Cushing's syndrome and diabetes mellitus: results from the SONICS phase 3 study

R Pivonello, A Elenkova, M Fleseriu… - Frontiers in …, 2021 - frontiersin.org
Background Cushing's syndrome (CS) is associated with numerous comorbidities, including
diabetes mellitus (DM). Levoketoconazole, an orally administered ketoconazole …

[HTML][HTML] Very low-calorie ketogenic diet: a potential application in the treatment of hypercortisolism comorbidities

V Guarnotta, F Emanuele, R Amodei, C Giordano - Nutrients, 2022 - mdpi.com
A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less
than 800 kcal/day), low carbohydrate intake (< 50 g/day) and normoproteic (1–1.5 g of …

[HTML][HTML] Distinguishing low and high water consumers—A paradigm of disease risk

LE Armstrong, CX Muñoz, EM Armstrong - Nutrients, 2020 - mdpi.com
A long-standing body of clinical observations associates low 24-h total water intake (TWI=
water+ beverages+ food moisture) with acute renal disorders such as kidney stones and …