Clinical efficacy of redifferentiation therapy with histone deacetylase inhibitor (HDACi) for
lethal radioiodine-refractory papillary thyroid cancer (RR-PTC) is urgently needed to be …

Thyroid hormones are essential for normal development and metabolism. Their synthesis
requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux …

The ClC family encompasses two classes of proteins with distinct transport functions: anion
channels and transporters. ClC-type transporters usually mediate secondary active anion …

The thyroid hormones thyroxine (T4) and triiodothyronine (T3) play key roles in regulating
development, growth and metabolism in pre‐and postnatal life. Iodide (I−) is an essential …

SLC5A8 is a member of the sodium/glucose cotransporter family. It has been proposed that
SLC5A8 might act as an apical iodide transporter in the thyroid follicular cells or as a …

The thyroid gland has the ability to uptake and concentrate iodide, which is a fundamental
step in thyroid hormone biosynthesis. Radioiodine has been used as a diagnostic and …

The X-linked disorder Lowe syndrome arises from mutations in OCRL1, a lipid phosphatase
that hydrolyzes phosphatidylinositol 4, 5-bisphosphate (PIP2). Most patients with Lowe …

Mutations of SLC26A4 cause an enlarged vestibular aqueduct, nonsyndromic deafness, and
deafness as part of Pendred syndrome. SLC26A4 encodes pendrin, an anion exchanger …

Targeted radioiodine therapy for thyroid cancer is based on selective stimulation of Na+/I−
Symporter (NIS)-mediated radioactive iodide uptake (RAIU) in thyroid cells by thyrotropin …

The thyroid gland accumulates the rare dietary element iodine and incorporates it into
iodinated thyroid hormones, utilising several tightly regulated reactions and molecular …