CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

Cancer stem cells (CSCs) represent a unique subpopulation of self-renewing oncogenic
cells that drive cancer initiation and progression. CSCs often acquire multidrug and …

Bladder cancer is one of the concerning malignancies worldwide, which is lacking effective
targeted therapy. Gene therapy is a potential approach for bladder cancer treatment. While …

Metastasis is the leading reason for the resultant mortality of patients with cancer. The past
few decades have witnessed remarkable progress in understanding the molecular and …

CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells.
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …

Antimitotics are important anticancer agents and include the natural alkaloid prodrug
colchicine (COL). However, a major challenge of using COL as an anticancer drug is its …

Hyaluronan accumulates in the stroma of several solid tumors and promotes their
progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a …

Curcumin is known to induce apoptosis of cancer cells by different mechanisms, but its
effects on cancer stem cells (CSC) have been less investigated. Here, we report that …

One of the most frequently utilized cancer stem cell markers in human cancers, including
colorectal cancer and breast cancer, is CD44. A glycoprotein, CD44, traverses the cell …

Cancer is a complex mechanism involving a series of cellular events. The glycoproteins
such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in …