Biomarkers are molecules that can be used to observe changes in an individual's
biochemical or medical status and provide information to aid diagnosis or treatment …

Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …

In Portugal, heterozygous loss-of-function mutations in the progranulin (GRN) gene account
for approximately half of the genetic mediated forms of frontotemporal dementia (FTD). GRN …

Frontotemporal dementia (FTD) is a devastating neurodegenerative disease affecting more
than a million people worldwide. Progranulin (PGRN) haploinsufficiency is the primary …

Transcriptional dysregulation is a hallmark of numerous neurological disorders, offering
targetable pathways with the potential to alter disease progression substantially. This …