The human plasma proteome is underexplored despite its potential value for monitoring
health and disease. Herein, using a recently developed aptamer-based platform, we profiled …

Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …

Mammalian parental imprinting represents an exquisite form of epigenetic control regulating
the parent-specific monoallelic expression of genes in clusters. While imprinting …

The placenta performs a range of crucial functions that support fetal growth during
pregnancy, including facilitating the supply of oxygen and nutrients to the fetus, removal of …

Delta like non-canonical Notch ligand 1 (Dlk1) is an imprinted gene, mainly known for its
involvement in adipogenesis, although it has been associated with many other stem …

Pubertal timing in humans is determined by complex interactions including hormonal,
metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is …

Pregnancy is a remarkable physiological state, during which the metabolic system of the
mother adapts to ensure that nutrients are made available for transfer to the fetus for growth …

Non-mendelian inheritance refers to the group of phenomena and observations related to
the inheritance of genetic information that cannot be merely explained by Mendel's laws of …

Abstract Context Silver-Russell syndrome (SRS)(mainly secondary to 11p15 molecular
disruption) and Temple syndrome (TS)(secondary to 14q32. 2 molecular disruption) are …

Abstract The imprinted Dlk1-Dio3 domain comprises the developmental genes Dlk1 and
Rtl1, which are silenced on the maternal chromosome in different cell types. On this parental …