Plague is a vector-borne disease caused by Yersinia pestis. Transmitted by fleas from
rodent reservoirs, Y. pestis emerged< 6000 years ago from an enteric bacterial ancestor …

Inhalation of the bacterium Yersinia pestis results in primary pneumonic plague. Pneumonic
plague is the most severe manifestation of plague, with mortality rates approaching 100% in …

Cronobacter sakazakii is an important pathogen associated with the development of
necrotizing enterocolitis (NEC), infant sepsis, and meningitis. Several randomized …

Subverting the host immune response to inhibit inflammation is a key virulence strategy of
Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of …

Activation of the inflammasome occurs in response to a notably high number of pathogenic
microbes and is a broad innate immune response that effectively contributes to restriction of …

To perform their functions proteins must interact with each other, but how these interactions
influence bacterial infection remains elusive. Here we demonstrate that connectivity in the …

Abstract The Black Death, also known as the Pestilence and the Great Mortality, was the
most fatal pandemic recorded in human history, resulting in the deaths of up to 200 million …

Antibiotic resistance in medically relevant bacterial pathogens, coupled with a paucity of
novel antimicrobial discoveries, represents a pressing global crisis. Traditional drug …

Rapid growth in deep tissue is essential to the high virulence of Yersinia pestis, causative
agent of plague. To better understand the mechanisms underlying this unusual ability, we …

The genus Yersinia includes human, animal, insect, and plant pathogens as well as many
symbionts and harmless bacteria. Within this genus are Yersinia enterocolitica and the …