Neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD) are inflammatory CNS
syndromes mainly involving the optic nerve and/or spinal cord and characterized by the …

Background Mitochondrial uncouplers shuttle protons across the inner mitochondrial
membrane via a pathway that is independent of adenosine triphosphate (ATP) synthase …

In the sanctity of pure drug discovery, objective reasoning can become clouded when
pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into …

Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …

Mild traumatic brain injury (mTBI) results in impairment of brain metabolism, which is
propagated by mitochondrial dysfunction in the brain. Mitochondrial dysfunction has been …

Aim. This study investigated changes in small‐world topology and brain functional
connectivity in patients with optic neuritis (ON) by resting‐state functional magnetic …

Traumatic brain injury (TBI) results in cognitive impairment, which can be long‐lasting after
moderate to severe TBI. Currently, there are no FDA‐approved therapeutics to treat the …

The incidence of common, metabolic diseases (eg obesity, cardiovascular disease,
diabetes) with complex genetic etiology has been steadily increasing nationally and …

Recent evidence suggests that misfolding, clumping, and accumulation of proteins in the
brain may be common causes and pathogenic mechanism for several neurological …

Background: Immune-mediated demyelination and consequent degeneration of
oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination …