As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

There is substantial debate about the intrinsic relationship between insulin resistance, the
metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD). While NAFLD has …

Non-alcoholic fatty liver disease (NAFLD) has reached epidemic proportions, affecting an
estimated one-quarter of the world's adult population. Multiple organ systems have been …

It has been increasingly recognized that inflammation plays an important role in the
pathogenesis of cardiovascular disease (CVD). In obesity, adipose tissue inflammation …

Neutral lipids in the form of triacylglycerol (TAG) have emerged as critical regulators of
cellular energy balance, lipid homeostasis, growth, development and stress response in …

The deposition of storage fat in the form of triacylglycerol (TAG) is an evolutionarily
conserved strategy to cope with fluctuations in energy availability and metabolic stress …