Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

Background: Moderate and high efficacy disease modifying therapies (DMTs) have a
profound effect on disease activity. The current treatment guidelines only recommend high …

Objective To investigate pregnancy-related disease activity in a contemporary multiple
sclerosis (MS) cohort. Methods Using data from the MSBase Registry, we included …

Background and Objectives To explore whether time to diagnosis, time to treatment
initiation, and age to reach disability milestones have changed in patients with clinically …

Background People with multiple sclerosis (MS) experience a wide range of unpredictable
and variable symptoms. The symptomatology of MS has previously been reported in large …

Objective The prevalence of multiple sclerosis (MS)-related fatigue may have changed due
to new diagnostic criteria and new disease modifying drugs. We aimed to assess the …

Chronic pain is the most disability symptom related to multiple sclerosis (MS) brain lesions
and can also generate anxiety and depression. There are no updated reports of the general …

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …

Introduction While magnetic resonance imaging (MRI) is established in diagnosing and
monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring …