NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
The CD70-CD27 axis in oncology: the new kids on the block
T Flieswasser, A Van den Eynde… - Journal of experimental …, 2022 - Springer
The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in
many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within …
many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within …
High-dimensional single-cell analysis identifies organ-specific signatures and conserved NK cell subsets in humans and mice
A Crinier, P Milpied, B Escaliere, C Piperoglou… - Immunity, 2018 - cell.com
Natural killer (NK) cells are innate lymphoid cells (ILCs) involved in antimicrobial and
antitumoral responses. Several NK cell subsets have been reported in humans and mice …
antitumoral responses. Several NK cell subsets have been reported in humans and mice …
Emerging targets in cancer immunotherapy
S Burugu, AR Dancsok, TO Nielsen - Seminars in cancer biology, 2018 - Elsevier
The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …
The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy
SL Buchan, A Rogel… - Blood, The Journal of the …, 2018 - ashpublications.org
In recent years, monoclonal antibodies (mAbs) able to reinvigorate antitumor T-cell immunity
have heralded a paradigm shift in cancer treatment. The most high profile of these mAbs …
have heralded a paradigm shift in cancer treatment. The most high profile of these mAbs …
CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset
S Lopez-Vergès, JM Milush, S Pandey… - Blood, The Journal …, 2010 - ashpublications.org
Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous
repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 …
repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 …
Maturation of mouse NK cells is a 4-stage developmental program
L Chiossone, J Chaix, N Fuseri, C Roth… - Blood, The Journal …, 2009 - ashpublications.org
Surface density of CD27 and CD11b subdivides mouse natural killer (NK) cells into 4
subsets: CD11blowCD27low, CD11blowCD27high, CD11bhighCD27high, and …
subsets: CD11blowCD27low, CD11blowCD27high, CD11bhighCD27high, and …
NK cells in autoimmune diseases: protective or pathogenic?
M Liu, S Liang, C Zhang - Frontiers in Immunology, 2021 - frontiersin.org
Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …
immune system to distinguish self from non-self), and are characterized by autoantibody …
CD27 is a thymic determinant of the balance between interferon-γ-and interleukin 17–producing γδ T cell subsets
JC Ribot, A Debarros, DJ Pang, JF Neves… - Nature …, 2009 - nature.com
The production of cytokines such as interferon-γ and interleukin 17 by αβ and γδ T cells
influences the outcome of immune responses. Here we show that most γδ T lymphocytes …
influences the outcome of immune responses. Here we show that most γδ T lymphocytes …
[PDF][PDF] Natural killer cells in liver disease
Z Tian, Y Chen, B Gao - Hepatology, 2013 - Wiley Online Library
Natural killer (NK) cells are enriched in lymphocytes within the liver and have unique
phenotypic features and functional properties, including tumor necrosis factor–related …
phenotypic features and functional properties, including tumor necrosis factor–related …