Secretion systems in Gram-negative bacteria: structural and mechanistic insights

TRD Costa, C Felisberto-Rodrigues, A Meir… - Nature Reviews …, 2015 - nature.com
Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells

JE Galán, M Lara-Tejero, TC Marlovits… - Annual review of …, 2014 - annualreviews.org
One of the most exciting developments in the field of bacterial pathogenesis in recent years
is the discovery that many pathogens utilize complex nanomachines to deliver bacterially …

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Y Zhao, J Yang, J Shi, YN Gong, Q Lu, H Xu, L Liu… - Nature, 2011 - nature.com
Inflammasomes are large cytoplasmic complexes that sense microbial infections/danger
molecules and induce caspase-1 activation-dependent cytokine production and …

Structure and regulation of the type VI secretion system

JM Silverman, YR Brunet, E Cascales… - Annual review of …, 2012 - annualreviews.org
The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial
export pathway with the capacity to translocate protein effectors into a diversity of target cell …

[HTML][HTML] The pathogenesis, detection, and prevention of Vibrio parahaemolyticus

R Wang, Y Zhong, X Gu, J Yuan, AF Saeed… - Frontiers in …, 2015 - frontiersin.org
Vibrio parahaemolyticus, a Gram-negative motile bacterium that inhabits marine and
estuarine environments throughout the world, is a major food-borne pathogen that causes …

Architecture of the major component of the type III secretion system export apparatus

P Abrusci, M Vergara-Irigaray, S Johnson… - Nature structural & …, 2013 - nature.com
Type III secretion systems (T3SSs) are bacterial membrane–embedded nanomachines
designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion …

[HTML][HTML] Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

J Hu, LJ Worrall, C Hong, M Vuckovic… - Nature …, 2018 - nature.com
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …

[HTML][HTML] Protein Secretion Systems in Pseudomonas aeruginosa: An Essay on Diversity, Evolution, and Function

A Filloux - Frontiers in microbiology, 2011 - frontiersin.org
Protein secretion systems are molecular nanomachines used by Gram-negative bacteria to
thrive within their environment. They are used to release enzymes that hydrolyze complex …

Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body

LJ Worrall, C Hong, M Vuckovic, W Deng… - Nature, 2016 - nature.com
The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical
for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid …

[HTML][HTML] Assembly and structure of the T3SS

BJ Burkinshaw, NCJ Strynadka - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Abstract The Type III Secretion System (T3SS) is a multi-mega Dalton apparatus assembled
from more than twenty components and is found in many species of animal and plant …